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 Viagraeffects and its development history

 Viagra Sildenafil,developed by the Pfizerpharmaceutical company, was first used to treat cardiovascular disease as a5-phosphodiesterase inhibitor to enter clinical studies. The researchers hopethat sildenafil by release the bioactive substance nitric oxide can make cardiovascularsmooth muscle relaxation, to achieve the object of dilation of blood vessels,cardiovascular disease remission. 

However, clinical studies have shown thatthe effect of sildenafil on cardiovascular can not meet the researchers expectation,as a cardiovascular drug,sildenafil performance was disappointing,can not growto be a successful treatment.

April 1991, clinical studies of sildenafil formallyfailed, but a side effect reported by subjects attracted the attention ofresearchers. The researchers found that, after the treatment had brought thereagent are reluctant to hand over the rest of the drugs. Under tracing, wefound that the drug has improved the patient's sex life.

After license by Pfizer high-level,researchers carried out research of sildenafil effect on corpus, and marketingauthorization the US Federal Food and Drug Administration on March 27, 1998,became a reputation product of Pfizer.

In 1998, the United States and European food anddrug regulatory authorities (FDA and EFSA) approved sildenafil (Viagra) listed totreat ED, its magical efficient arouse worldwide sensation. Sildenafil resultsof clinical studies published in leading medical journal "New EnglandJournal of Medicine".

In 1999, "Viagra" is the termincluded in the Oxford English Dictionary, at the same time, clinical researchconfirmed its cardiovascular safety.

In 2000, the study further confirmed thesafety of sildenafil in blood pressure, as well as safety in combination withantihypertensive drugs. Articles published in the "Journal ofHypertension";

In November 2000, Viagra won the French PrixGalien award

2001, Viagra has been approved in the global market morethan 100 countries, an average of 9 pills prescriptions per second.

In 2002, human clinical studies confirmsildenafil had no effect on sperm function, the article published in the"British Journal of Clinical Pharmacology";

In 2003, 120 controlled studies confirmedthat sildenafil does not increase risk of MI / cardiovascular death, thearticle published in "International Journal of Clinical Practice";

In 2004, studies confirm that sildenafil byimproving erections, improve the patient's self-confidence, self-esteem,relationship with a sexual partner, and overall quality of life (SEAR and QoL)

2005, Viagra has more than 750,000prescriptions, over 23 million men use

In 2006, the study further confirmed thatViagra help men achieve erection hardness level 4 (optimal erection hardness),article published in Journal of Sexual Medicine

In 2007, the four-year long-term studiesconfirm Viagra's long-term safety and efficacy, the article published inTherapeutics and Clinical Risk Management

In 2008, researchers confirmed thaterection hardness is important treatment expectation for ED patients, SCOREDstudy published in International Journal of Impotence Research

In 2009, the ultrasound study confirmed, Viagra100mg therapy significantly improved blood flow in the penis, the article publishedin Journal of Sexual Medicine

In 2010, the meta-analysis to furtherverify its safety (67 double-blind, placebo-controlled study), the articlepublished in International Journal of Clinical Practice

2013, Viagra new packaging on the market

2015, sildenafil in Pubmed database containedliterature has more than 5800, there are more than 780 million men use Viagra

        

ViagraExperience Survey

A 2618 patients were enrolled for up to2--3 years open-label studies (patient has completed preliminary studiescontinue to participate in one-year extension studies) show that:

95.3% of patients believe that in the longcourse of treatment, Viagra has always been able to increase its sexual potency(the principal investigator is for people in the United States New York,Washington,California, Florida, Georgia,New jersey, New mexico, Pennsylvania, Marylandetc. want to buy wholesale best original viagra pills,contact : sears-68@hotmail.com ) 

Viagra common adverse reactions wereheadache, flushing, indigestion, usually mild to moderate and short duration

Compared with placebo, taking Viagrawithout increasing the incidence of serious adverse events in patients

Patients taking any form of nitrates areViagra absolute contraindications

Before sex about one hour oral taking,undersexual stimulation natural erection

82% of patients believe that after takingviagra they are more intimate with your spouse (main survey area is ​​the United States: Alabama, Alaska, Indiana, Connecticut, Kentucky,New york, Nevada, Wyoming, Texas, Mississippi, New jersey, Ohio, Rhode island,Massachusetts, New hampshire, Minnesota, Pennsylvania, North carolina,Michigan) 

Some young people of childbearing age, dueto the pressure of life, work and the fertility other aspects, can cause ovulationED, that is, during the planned pregnancy, erectile dysfunction,when can byusing Viagra successfully completed childbearing tasks.in many clinicalexperiments have not found Viagra has affect on sperm. 

86% of patients improved quality of sex life(the main survey area of ​​the United States:Kansas, Maine, Missouri, South carolina, Virginia, Washington, Oklahoma,Louisiana, Tennessee, West virginia, Montana, Arizona, California, Hawaii,Idaho)

90% of patients become more confident onthe sex life (the main survey area of ​​the United States:Colorado, Florida, Maryland, Nebraska, Utah, North dakota, South dakota, Newmexico, Wisconsin, Oregon, Vermont, Iowa, Georgia, Illinois, Delaware ,Arkansas)

ED is a disease associated with manychronic diseases,

Diagnosis of ED, can help doctors earlier foundpatients with certain underlying chronic disease

Undeniably,Viagra is the world's best andmost popular effective ED PE products, made a revolution contribution to theglobal men.

 

Taking Viagra Precautions 

1: Viagra must not mix with treat heartdisease nitrates (such as nitroglycerin, isosorbide dinitrate), or maysignificantly lower blood pressure, leading to life-threatening;

drinking can seriously reduce theeffectiveness of Viagra erection, so should not overdose drinking. In addition,it is best not to immediately take just showered.

2: Before using the "Viagra"drugs, first we need to know two things:

First, if he has several more seriousillness; second, whether the user is able to afford the sexual life requiredtremendous energy and stamina expenditures.

If you suffer from heart disease, stroke,retinitis pigmentosa, kidney disease, liver disease, blood disease, peniledeformity, before taking sure to consult an expert. People who are takingnitroglycerin, isosorbide dinitrate and other nitrates drugs can notarbitrarily take Viagra. Finally, poor physical,poor heart affordability peoplecan not use. 

3: Taking Viagra itself does not cause orincrease the libido, but its role in the event of sexual impulses, to help erectiledysfunction patients restore normal erectile function. Simply put, it is tohelp restore a person's normal sexual function, so that patients in the naturalerection when sexual impulses.

Studies have evidence that Viagra caneffectively prolong ejaculation latency, improve erectile hardness, long-termintermittent or continuous take, it is possible to improve penile endothelialfunction, and further improve the quality of erections. Usually poor erectilefunction people, can try to use Viagra to improve erection, but people who has gooderection do not abuse.

4: Viagra should not drink the same time,not to say that can not drink, problem is drinking can seriously reduce theeffectiveness of Viagra erection.

5: cimetidine, erythromycin, ketoconazole,itraconazole and Mibeilei and other CYP 3A4 inhibitors can reduce themetabolism Viagra, may increase the Viagra plasma concentration. Rifampicin isthe most clinically CYP 3A subfamily enzyme inducer, can enhance the activityof CYP 3A4, reduce the effects of Viagra

 

Viagraprices

Viagra has been on the market is not astranger, large pharmacies and online is available,or can buy at regularpharmacies or hospital.

Price: original Viagra in the USretail price is $ 8-12 per one pill, and requires a prescription to buy (but inmany countries do not need a prescription to buy Viagra, as long as an adult,itcan not sure why).

In the United States,there are some large population states the retailprice will be 10-20% cheaper than other places such as: Mississippi,New jersey, New york,Washington, Pennsylvania,Florida, Georgia,New mexico, California.

If you want to buy lower prices of viagrapills then only can wholesale. The wholesale prices is lower than retail price,we know where can wholesale cheap Viagra, you can wholesale start from 100pieces of viagra,no need prescription, also free shipping. The price is verygood. If you're resell to others at low price,can also get profits, remember tocontact us. Or send mail to edgo.a@hotmail.com,there will be surprises.

 

Whereto buy Viagra in US 

In the United States most places you canbuy Viagra, as in the following cities,we offer free shipping to :

1 Alabama - ALMontgomery, Birmingham. Franklin Mobile,Morgan, Tuscaloosa

2 Alaska - AK AnchorageB. Valdez-Cordova C.A. Nome C.A.

3Arizona - AZ : Pima County, Yavapai County, Arizona, Mohave County, Arizona,Maricopa County, Cochise County, Arizona)

4 Arkansas - AR : Benton,Sebastian, Washington,Pulaski, Lonoke, Mississippi, Craighead, Crawford

5 California -CA : Los Angeles, Ventura,San Francisco,San Diego,San Bernardino, sacramento Riverside, Orange, Alameda,Ventura,Contra Costa, Kern San Mateo, Santa Clara,Fresno,Monterey, Stanislaus, Sonoma

6 Colorado - CO AdamsCounty, ArapahoeCounty, BoulderCounty, City and County of Denver, El Paso County, Jefferson County,Larimer County,Weld County

7 Connecticut -CT : Fairfield County, South Carolina, Hartford, City of New Haven,NewBritain, Westport,Greenwich Darien

8 Delaware – DE New Castle County, Delaware,Kent County, Sussex County, New Jersey

9 Florida- FL : Broward, Miami-Dade, Palm Beach, Pinellas, Orange, Lee,Hillsborough,Duval, Brevard, West Palm Beach, Orlando, Miami,Hialeah, Hollywood, PembrokePines, Tampa, Jacksonville, St. Petersburg,Sarasota ,, Pensacola

10 Georgia- GA : Atlanta, Bartow County, Clarke County, Clayton County, Cobb County,ColumbiaCounty, Coweta County, DeKalb County, Gwinnett County,Hall County, WhitfieldCounty, Houston County, Henry County, Fulton County,Forsyth County, DouglasCounty, Chatham County Augusta

11 Hawaii – HI :

12 Idaho  – ID : Ada, Bannock, Bonneville, Kootenai,Nez Perce, Twin Falls

13 Illinois – IL : ChampaignCounty, Cook County, Chicago, DeKalb County,DuPage County, Wheaton Lake County,Waukegan Will County, Joliet Winnebago County, Tazewell County Pekin St. ClairCounty, Belleville,Sangamon County, Rock Island County, Rock Island McHenryCounty,McLean County, Woodstock Bloomington Kane County, Kankakee County,GenevaKankakee

14 Indiana- IN : Allen County, Hamilton County, Hendricks County, Lake County,CrownPoint, Marion County, Indianapolis, Monroe County,Porter County, St. Joseph County VanderburghCounty, Terre Haute

15 Iowa – IA :

16 Kansas – KS : Hays,Johnson County, Butler County, Douglas County,Leavenworth County, Reno County,Sedgwick County, Wichita Wyandotte County

17 Kentucky – KY : Frankfort,Louisville Lexington, Adair County, Allan County Bath County,Casey County,Clinton County, Crittenden County, Hardin County,Jessamine County

18 Louisiana – LA : Houma, Louisiana, St. TammanyParish

20 Maine – ME : Auburn Augusta Bangor Bar Harbor Kennebunkport,LewistonOld OrchardBeach Orono Portland South Portland

21 Maryland – MD : Baltimore Annapolis Silver Springs Rockville Potomac,GaithersburgCollege Park WheatonHagerstown

22 Massachusetts – MA BostonWorcester CambridgeSpringfield Springfield,Barnstable

22 Michigan – MI: Detroit

23 Minnesota - MN:Saint Paul,Minnesota Minneapolis

24 Mississippi – MS : Jackson Biloxi Meridian Hattiesburg Greenville Gulfport Vicksburg

25 Missouri – MO: Kansas City,Missouri Jackson Clay Cass Platte Jefferson City,St. Louis Springfield Columbia

26 Montana – MT: BillingsHelena

27 Nebraska – NE :OmahaLincoln

28 Nevada – NV : Carson cityLas Vegas North Las Vegas Reno,ElkoVirginia City Sparks Carson City Henderson

28 New Hampshire – NH :  CONCORDKeene

29 New Jersey - NJ:TrentonNewark Jersey CityPaterson Elizabeth,Camden Clifton East Orange,Passaic Union City,Bayonne Atlantic City Hoboken Morristown Princeton

30 New mexico - NM :Santa Fe Albuquerque Las CrucesTaos Roswell

31 New York – NY :New York CityCity of New York AlbanyBuffalo,RochesterYonkers Syracuse

32 North Carolina – NC : Raleigh Charlotte ChapelHill Durham Greensboro,Winston-Salem Asheville

33 NorthDakota – ND Bismarck Fargo BismarckGrand Forks Minot

34 Ohio - OH Parma MentorLakewood Euclid Kent,Warren Youngstown CincinnatiBowling Green,SanduskyFindlay Lima Toledo Mansfield,Mansfield Ashland Dayton

35 Oklahoma OK : Oklahoma City Tulsa artlesville Broken Arrow,NormanBartlesville Edmond Enid Lawton Midwest City Moore Muskogee

36 Oregon OR :Portland BeavertonLake OswegoCorvallis Eugene,Hood River Medford Salem The Dalles Dallas,Springfield Tillamook StHelens Crater Lake Bend

37 Pennsylvania PA Harrisburg Philadelphia Allentown Altoona,Bethlehem Erie Lancaster Pittsburgh StateCollege

38 Rhode Island  RI : Providence

39 South Carolina  SC :Columbia Charleston North Charleston Greenville,Spartanburg Anderson Rock Hill Sumter Florence

40 South Dakota SD :Sioux FallsPierre

41 Tennessee TN : Nashville Memphis Chattanooga Knoxville Smyrna,Spring Hill Johnson CityKingsport Bristol

42 Texas TX : Austin Houston SanAntonio Dallas Fort Worth El Paso

43 Utah UT :Salt Lake City Beaver, BoxElder, Cache, Carbon, Daggett, Davis, Duchesne,Emery, Garfield, Grand, Iron, Juab, Kane, Millard, Morgan, Piute, Rich,SaltLake, SanJuan, Sanpete, Sevier, Summit, Tooele, Uintah , Utah, Wasatch,Washington, Wayne, Weber

44 Vermont – VTBurlington ontpelier Bennington Windsor StoweSpringfield,Colchester Essex Hartford Manchester Middlebury,Newport Norwich St.Albans South Burlington Montp

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