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"BMC Medicine" October 19 announced a new study, researchers found that Viagra may be able to be safely used to treat heart disease. The study showed that in the various course of heart disease, long-term daily doses of Viagra can play a role in protecting the heart, and almost no side effects.


The main component of Viagra is a phosphodiesterase 5 inhibitor (phosphodiesterase-5 inhibitor, PDE5i), but also the other main component of the treatment of erectile dysfunction commonly used drugs. PDE5 phosphorylation effect is to prevent the relaxation of smooth muscle tissue, and phosphodiesterase inhibitors can block this action.

It was found that heart also has PDE-5, so scholars began to study the PDE-5 inhibitors can treat non-urinary system diseases or not. Although previous research has some promising results, but most experimental studies in animals, and PDE5i cardioprotective effect remains unclear.

Scientists at the University of Rome by retrieving published between January 2004 to May 2014 in literature, a plurality of randomized controlled trials conducted a meta-analysis (Meta analysis), and thus  to verify the validity of the PDE5i cardioprotective effects, and determine whether the human body has its good tolerance and human safety of taking the drug.

Researchers finally from the screening MEDLINE, EMBASE, test Corran Library (Cochrane Library) and SCOPUS databases four matches out of 24 trials for analysis. These tests include 1662 patients, covering more races, respectively using PDE5i and placebo for treatment.

In this study, scientists first time for  phosphodiesterase type 5 inhibitors on the size and shape affect the heart and the effects were analyzed in parallel.


Left ventricular hypertrophy can lead to thickening of the left ventricular myocardium. The results show, PDE5i can prevent left ventricular hypertrophy patients' heart continue to increase and morphological changes. For patients suffering from various heart diseases, phosphodiesterase type 5 inhibitors can improve heart function, and will not adversely affect the patient's blood pressure.

Author Andre Isidor (Andrea Isidori) said: "We found that, for some patients with heart disease, the main component of Viagra is a safe and effective treatment, these findings are encouraging, scientists need extensive clinical trials immediately. "

The study concluded that the PDE-5 inhibitors for the treatment of patients with myocardial hypertrophy and early heart failure patients is reasonable. However, the meta-analysis include mostly for male patients, so researchers believe that the next step should be gender-specific long needle drug reaction expand larger trials.

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